Prior studies have demonstrated an organic anion transporter 6 (OAT6)-mediated\naccumulation of sorafenib in keratinocytes. TheOAT6 inhibitor probenecid decreases sorafenib uptake\nin skin and might, therefore, decrease sorafenib-induced cutaneous adverse events. Here, the influence\nof probenecid on sorafenib pharmacokinetics and toxicity was investigated. Pharmacokinetic sampling\nwas performed in 16 patients on steady-state sorafenib treatment at days 1 and 15 of the study.\nPatients received sorafenib (200â??800mgdaily) in combination with probenecid (500mgtwo times daily\n(b.i.d.)) on days 2â??15. This study was designed to determine bioequivalence with geometric mean Area\nunder the curve from zero to twelve hours ......................
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